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She also made a brief appearance in Alice Doesn't Live Here Anymore (1974), one of Ladd's signature roles.Her mother objected to her 13-year-old daughter's presence on the set of Ladies and Gentlemen, The Fabulous Stains, but Dern sued for and received emancipation.
Dern won the Golden Globe Award for Best Actress – Miniseries or Television Film for the 1992 film Afterburn, and guest-starred in the 1997 "Puppy Episode" of the sitcom Ellen.She guest-starred on The West Wing, was a voice on King of the Hill, and was a lesbian who coaxes Ellen De Generes out of the closet in the famous 1997 "The Puppy Episode" of the television series Ellen.On the April 24, 2007, airing of De Generes's talk show, Dern revealed she did not work for more than a year following her appearance in that episode because of resulting backlash, but nevertheless called it an "extraordinary experience and opportunity." Dern has been acknowledged with several awards from the independent film industry including the Sundance Institute and was the subject of an aggressive media campaign by David Lynch to win her an Academy Award nomination for her work in Inland Empire.In 1992, Dern and her mother became the first mother and daughter to be nominated for an Academy Award for acting in the same film in Rambling Rose although, unlike in Wild at Heart, they did not play mother and daughter in the film. Ellie Sattler in Steven Spielberg's 1993 film Jurassic Park.That same year, Clint Eastwood contacted the actress for his film A Perfect World.
In 1982, she became the youngest-ever winner of Miss Golden Globe.